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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment choice for chronic weight loss in addition to a reduced-calorie diet and physical activity.

Using two separate drugs to lose weight naturally can be very effective you can find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people that go through it one should err to the side of caution and allow the FDA do its job and demand some investigation be done in order that the public knows the side effects and perils associated with the medications before we take them. Keep in mind that drug companies come in business to generate income and that they would say everything to keep people on their medications.

Researchers found out that participants taking this drug for the year, dropped excess weight within four weeks and have kept the extra weight off through the entire 56 weeks in the study. Contrave can be a combination of the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which can be made up of more than one active ingredient, which might make them more potent and safer.

Combo-pilling could be the newest fad or better yet the newest to come under scrutiny and for that reason it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is now popular may be the fact that as of right now there are no long term prescription weight loss supplements that have been authorized by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be authorized by the FDA.

Seizures certainly are a side effect with Contrave and must not be taken in individuals with seizure disorders. The drug could also raise blood pressure and heartrate, and really should not be used in people who have a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise hypertension and heartrate and must not be used in patients with uncontrolled high hypertension, as well as by you are not heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients using a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients towards the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking.


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