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Evidence is increasing that every addiction without exception is related to issues with the brain's reward center, particularly the mesolimbic system. This part of the problem regulates reward responses in acquiring food and sex, along with nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both whenever they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to shed pounds can be very effective you will find combinations while watching FDA now awaiting approval. When dealing with weight-loss and the people who go through it you should err on the side of caution and allow FDA do its job and demand some study be done in order that the public knows the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies will be in business to generate money and that they would say almost anything to keep people on their own medications.

Researchers found that participants using this drug for a year, dropped a few pounds within four weeks and have kept the extra weight off throughout the 56 weeks from the study. Contrave is a combination in the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs that are made up of multiple active ingredient, that might make them more potent and safer.

Combo-pilling may be the newest fad or also the newest to come under scrutiny and thus it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular could be the fact that by right now there aren't long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug also can raise blood pressure levels and heartrate, and really should not be used in individuals with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise hypertension and heart rate and must stop used in patients with uncontrolled high hypertension, along with by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients with a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients to the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation.


The most common negative effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.